Healing Investigational

TB-500

Also known as: Thymosin Beta-4 Fragment, Tβ4 Fragment 17-23

The active fragment of Thymosin Beta-4 that drives cell migration and angiogenesis — half of the gold-standard BPC-157 + TB-500 healing stack.

Popularity A+
Class Thymosin Beta-4 Derivative
Half-Life ~3-4 hours
Form Lyophilized powder
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TB-500 C212H350N56O78S
Research-Backed User Reports Sourced Updated Mar 2026
// Overview

What is TB-500?

TB-500 is a synthetic peptide representing the active region (amino acids 17-23) of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein found in nearly all human cells. Thymosin Beta-4 is the primary intracellular G-actin sequestering protein, playing a fundamental role in cell motility, migration, and tissue repair.

While the full Thymosin Beta-4 protein is large and expensive to synthesize, the TB-500 fragment retains the key actin-binding domain responsible for its therapeutic effects. This fragment promotes cell migration to injury sites, stimulates new blood vessel formation (angiogenesis), reduces inflammation, and supports the formation of new muscle and skin tissue.

TB-500 is often paired with BPC-157 in what the peptide community calls the “healing stack” — BPC-157 drives growth factor signaling while TB-500 handles cellular migration and tissue remodeling, creating complementary healing pathways.

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// How It Works

How TB-500 Works

TB-500 promotes healing through actin-mediated cellular repair:

  1. Actin binding and cell migration — The LKKTETQ sequence binds G-actin, promoting actin polymerization which drives cell motility. This allows immune cells, fibroblasts, and stem cells to migrate to injury sites faster.
  2. Angiogenesis — Stimulates formation of new blood vessels from existing vasculature, improving blood supply to damaged tissues. This is critical for healing avascular or poorly vascularized injuries.
  3. Anti-inflammatory action — Downregulates inflammatory cytokines and chemokines, reducing the inflammatory phase and allowing earlier transition to the repair/remodeling phase.
  4. Matrix metalloproteinase regulation — Modulates MMP activity to support tissue remodeling without excessive scarring or fibrosis.
  5. Stem cell activation — Promotes differentiation and migration of resident stem cells, particularly cardiac progenitor cells and keratinocyte stem cells.
// Dosage Protocols

Dosage Information (User-Reported)

Disclaimer: Dosage information is compiled from user reports and published research. This is not medical advice. Consult a healthcare professional before use.
Level Dose Frequency Duration
Loading 2-2.5 mg 2x per week 4-6 weeks
Maintenance 2 mg 1-2x per week 4-8 weeks
Acute Injury 2.5 mg 2x per week 2-4 weeks
Systemic 5 mg 1x per week 8-12 weeks

What to Expect

Week 1-2

Reduced inflammation at injury sites. Improved flexibility and reduced stiffness. Some users notice better hair/nail growth early.

Week 3-4

Healing of chronic injuries accelerating. Range of motion improving. Skin healing faster. Workout recovery noticeably better.

Week 5-8

Significant tissue repair. Chronic tendon/joint issues resolving. Hair density may improve. Scars fading.

Week 8-12

Continued remodeling of healed tissue. Best results when combined with BPC-157 for the full healing stack.

Common Stacks

BPC-157

Gold Standard Healing Stack

TB-500 (cell migration/angiogenesis) + BPC-157 (growth factors) = complementary healing from two distinct pathways

GHK-Cu

Collagen Remodeling

TB-500 delivers cells to injury sites while GHK-Cu provides copper for collagen crosslinking and structural repair

Ipamorelin

GH-Enhanced Recovery

Growth hormone amplifies the tissue repair and remodeling processes TB-500 initiates

// Preparation

Reconstitution & Storage

Reconstitute with bacteriostatic water. For a 5mg vial, add 2mL BAC water for 2.5mg/mL.

Inject water slowly down the vial wall. Do not shake. Swirl gently until fully dissolved.

Store reconstituted vial refrigerated. Use within 21 days.

Storage: Lyophilized: room temperature or refrigerated. Reconstituted: 2-8°C, use within 21 days.

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// Safety Profile

Side Effects & Safety

Potential Side Effects

  • ! Injection site irritation
  • ! Lethargy or drowsiness (temporary)
  • ! Head rush or lightheadedness
  • ! Mild headache
  • ! Numbness or tingling at injection site
  • ! Generally well tolerated with mild side effect profile

Contraindications

  • ⚠ Active malignancy (angiogenesis may feed tumor blood supply)
  • ⚠ Pregnancy or breastfeeding
  • ⚠ Recent surgery with active internal bleeding
  • ⚠ Known hypersensitivity to thymosin peptides

Legal & Regulatory Status

Not FDA-approved. Banned by WADA for competitive athletes. Available as a research peptide from vendors. Not a controlled substance. Widely used in veterinary medicine (equine).

// Research

Published Research

// Where to Buy

Top Vendors for TB-500

Ranked by our review scores. All vendors are independently tested.

B+
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// Related Compounds

Other Healing Guides

Cagrilintide

A long-acting amylin analog that amplifies weight loss when paired with semaglutide — the amylin component of CagriSema's…

Read Guide →

BPC-157 Arginate (Oral)

The oral form of BPC-157 — gastric-acid stable and designed for direct GI tract healing. No injections needed…

Read Guide →

TB-500 Fragment

A concentrated fragment of Thymosin Beta-4 focused on the core actin-binding domain — smaller molecule, targeted tissue repair.

Read Guide →

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This content is for informational and educational purposes only. TB-500 is sold for research purposes. Never Natty does not condone or encourage the use of any substance in violation of any laws. Consult a healthcare professional before using any compound discussed on this site.