Neuropeptide Investigational

VIP

Also known as: Vasoactive Intestinal Peptide, VIP Nasal Spray, Aviptadil

A master regulatory neuropeptide with broad anti-inflammatory, vasodilatory, and neuroprotective effects — critical in mold illness (CIRS) treatment and chronic inflammation.

Popularity B
Class Neuropeptide
Half-Life ~1-2 minutes (IV); intranasal effects persist hours
Form Nasal spray (compounded), Lyophilized powder
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VIP C147H237N43O43S
Research-Backed User Reports Sourced Updated Mar 2026
// Overview

What is VIP?

VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide widely distributed throughout the body — found in the brain, gut, lungs, immune system, and vasculature. It was first isolated from porcine small intestine in 1970 and has since been recognized as a master regulatory peptide with effects spanning multiple organ systems.

VIP gained particular prominence through the work of Dr. Ritchie Shoemaker, who identified it as a critical biomarker and treatment target in Chronic Inflammatory Response Syndrome (CIRS), commonly triggered by mold/biotoxin exposure. CIRS patients often have depleted VIP levels, and replacement therapy addresses multiple downstream symptoms including pulmonary hypertension, inflammatory cascades, and hormonal dysregulation.

Beyond CIRS, VIP has documented anti-inflammatory, neuroprotective, and immunomodulatory properties that make it relevant for autoimmune conditions, neurodegenerative diseases, and chronic inflammatory states.

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// How It Works

How VIP Works

VIP acts through VPAC1 and VPAC2 receptors across multiple organ systems:

  1. Anti-inflammatory — Suppresses NF-κB activation and reduces TNF-α, IL-6, and other inflammatory cytokines. Promotes Th2/Treg immune balance over Th1/Th17 inflammatory profiles.
  2. Vasodilation — Relaxes smooth muscle in blood vessels, bronchi, and the GI tract through cAMP-mediated pathways. Reduces pulmonary arterial pressure.
  3. Neuroprotection — Protects neurons from excitotoxicity, oxidative stress, and inflammation. Promotes neuronal survival via BDNF-like signaling.
  4. Circadian regulation — VIP is a key neurotransmitter in the suprachiasmatic nucleus (SCN), regulating circadian rhythm and sleep-wake cycles.
  5. CIRS restoration — In biotoxin illness, VIP levels are depleted. Replacement normalizes regulatory T-cell function, reduces C4a, corrects pulmonary artery pressures, and restores hormonal regulation.
// Dosage Protocols

Dosage Information (User-Reported)

Disclaimer: Dosage information is compiled from user reports and published research. This is not medical advice. Consult a healthcare professional before use.
Level Dose Frequency Duration
CIRS Protocol 50 mcg per nostril 4x daily (intranasal) Until markers normalize (weeks to months)
Anti-Inflammatory 50 mcg per nostril 2-3x daily 4-8 weeks
Maintenance 50 mcg per nostril 1-2x daily As needed

What to Expect

Day 1-3

Some users notice improved breathing and reduced sinus congestion. Mild headache possible as inflammation begins resolving.

Week 1-2

CIRS patients: inflammatory symptoms begin improving. Cognitive clarity returning. Fatigue lessening. Breathing easier.

Week 3-6

Significant symptom improvement in CIRS patients. Inflammatory markers trending downward on bloodwork. Sleep quality improved.

Month 2-3

Comprehensive recovery in CIRS. Pulmonary pressures normalizing. Regulatory T-cells restored. Patients report substantial quality of life improvement.

Common Stacks

BPC-157

Gut + Systemic Healing

VIP's gut-protective effects complement BPC-157's mucosal healing for comprehensive GI recovery

KPV

Anti-Inflammatory Duo

VIP (NF-κB suppression via VPAC receptors) + KPV (NF-κB suppression via α-MSH pathway) = dual-mechanism inflammation control

Glutathione

CIRS Protocol

IV or liposomal glutathione supports detoxification alongside VIP's immune normalization in biotoxin illness

// Preparation

Reconstitution & Storage

VIP nasal spray is typically obtained from compounding pharmacies pre-mixed at 50mcg per spray.

For research use: Reconstitute lyophilized VIP with sterile water. Handle carefully — VIP is sensitive to temperature, agitation, and light.

Store all forms refrigerated. Protect from light.

Storage: Lyophilized: -20°C to 2-8°C. Reconstituted nasal: 2-8°C, use within 30 days. Very temperature-sensitive.

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// Safety Profile

Side Effects & Safety

Potential Side Effects

  • ! Nasal irritation
  • ! Runny nose / congestion (transient)
  • ! Mild headache
  • ! Diarrhea (VIP relaxes GI smooth muscle)
  • ! Hypotension (VIP is a vasodilator — monitor blood pressure)
  • ! Nasal passage dryness

Contraindications

  • ⚠ Hypotension (VIP further lowers blood pressure)
  • ⚠ Active diarrheal illness (VIP promotes GI secretion)
  • ⚠ Pregnancy or breastfeeding
  • ⚠ VIP should only be used in CIRS after completing Shoemaker protocol steps 1-11

Legal & Regulatory Status

Not FDA-approved (Aviptadil was studied for COVID-19 ARDS). Available from compounding pharmacies with prescription. Research-grade available from peptide vendors. Not a controlled substance.

// Research

Published Research

// Where to Buy

Top Vendors for VIP

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// Related Compounds

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BPC-157 Arginate (Oral)

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TB-500 Fragment

A concentrated fragment of Thymosin Beta-4 focused on the core actin-binding domain — smaller molecule, targeted tissue repair.

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This content is for informational and educational purposes only. VIP is sold for research purposes. Never Natty does not condone or encourage the use of any substance in violation of any laws. Consult a healthcare professional before using any compound discussed on this site.