GH Secretagogue Investigational

CJC-1295 DAC

Also known as: CJC-1295 with DAC, DAC:GRF, Drug Affinity Complex GHRH

A long-acting GHRH analog that binds to albumin for a 6-8 day half-life — provides sustained GH/IGF-1 elevation with once-weekly dosing.

Popularity A
Class GHRH Analog (Long-Acting)
Half-Life 6-8 days
Form Lyophilized powder
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CJC-1295 DAC C152H252N44O42
Research-Backed User Reports Sourced Updated Mar 2026
// Overview

What is CJC-1295 DAC?

CJC-1295 DAC (Drug Affinity Complex) is a synthetic analog of growth hormone-releasing hormone (GHRH 1-29) modified with a maleimido-propionyl group that covalently binds to serum albumin in the bloodstream. This “Drug Affinity Complex” dramatically extends the peptide’s half-life from minutes to 6-8 days, enabling once or twice weekly dosing.

Originally developed by ConjuChem Biotechnologies, CJC-1295 DAC produces a sustained elevation of growth hormone and IGF-1 levels rather than acute pulses. In clinical studies, a single injection increased mean GH levels 2-10 fold and IGF-1 levels 1.5-3 fold for 6-14 days.

The sustained GH elevation profile makes CJC-1295 DAC popular for anti-aging, body composition, and recovery goals — but the “always on” GH signal is a double-edged sword. Some prefer the pulsatile release pattern of CJC-1295 without DAC (also called Modified GRF 1-29), which more closely mimics natural GH secretion.

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// How It Works

How CJC-1295 DAC Works

CJC-1295 DAC stimulates sustained GH release via albumin-binding technology:

  1. GHRH receptor agonism — Binds to GHRH receptors on anterior pituitary somatotrophs, stimulating growth hormone synthesis and secretion.
  2. Albumin conjugation (DAC) — The maleimidopropionyl group forms a covalent bond with circulating serum albumin, protecting the peptide from enzymatic degradation and creating a depot effect.
  3. Sustained GH elevation — Rather than producing sharp pulses (like natural GHRH), CJC-1295 DAC creates a sustained 2-10x elevation of baseline GH levels over 6-8 days.
  4. IGF-1 amplification — Chronic GH elevation stimulates sustained hepatic IGF-1 production, with levels remaining elevated for up to 2 weeks after a single dose.
// Dosage Protocols

Dosage Information (User-Reported)

Disclaimer: Dosage information is compiled from user reports and published research. This is not medical advice. Consult a healthcare professional before use.
Level Dose Frequency Duration
Standard 1-2 mg Once weekly 8-12 weeks
Advanced 2 mg Twice weekly 8-12 weeks
Combined (with GHRP) 1 mg Once weekly + daily GHRP 8-12 weeks

What to Expect

Week 1-2

Improved sleep quality. Water retention may increase temporarily. Mild tingling or flushing post-injection.

Week 3-4

Sustained energy improvement. Recovery from exercise improving. Appetite may increase.

Week 5-8

Body composition changes — increased lean mass, reduced fat. Skin and hair quality improving.

Week 8-12

Peak effects. IGF-1 levels substantially elevated. Significant recovery and anti-aging benefits. Some users prefer cycling to prevent desensitization.

Common Stacks

Ipamorelin

GHRH + GHRP Synergy

The sustained CJC-1295 DAC base combined with daily ipamorelin pulses — popular long-acting GH stack

BPC-157

Recovery Enhancement

GH elevation supports tissue repair; BPC-157 provides targeted healing

MK-677

Oral GH Support

Adding oral GH secretagogue for convenience alongside injectable CJC-1295 DAC

// Preparation

Reconstitution & Storage

Reconstitute with bacteriostatic water. For a 2mg vial, add 2mL BAC water for 1mg/mL.

Inject water slowly. Do not shake. Swirl gently.

Refrigerate after reconstitution. Use within 21 days.

Storage: Lyophilized: -20°C to 2-8°C. Reconstituted: 2-8°C, use within 21 days.

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// Safety Profile

Side Effects & Safety

Potential Side Effects

  • ! Water retention / bloating
  • ! Tingling or flushing post-injection
  • ! Increased appetite
  • ! Joint stiffness
  • ! Fatigue or drowsiness
  • ! Headache
  • ! Dizziness
  • ! Potential glucose elevation (monitor fasting glucose)

Contraindications

  • ⚠ Active malignancy
  • ⚠ Pregnancy or breastfeeding
  • ⚠ Diabetes (GH affects insulin sensitivity)
  • ⚠ Pituitary disorders
  • ⚠ History of carpal tunnel syndrome

Legal & Regulatory Status

Not FDA-approved. Research peptide. Not a controlled substance. Available from peptide vendors for research purposes.

// Research

Published Research

// Where to Buy

Top Vendors for CJC-1295 DAC

Ranked by our review scores. All vendors are independently tested.

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// Related Compounds

Other GH Secretagogue Guides

Cagrilintide

A long-acting amylin analog that amplifies weight loss when paired with semaglutide — the amylin component of CagriSema's…

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BPC-157 Arginate (Oral)

The oral form of BPC-157 — gastric-acid stable and designed for direct GI tract healing. No injections needed…

Read Guide →

TB-500 Fragment

A concentrated fragment of Thymosin Beta-4 focused on the core actin-binding domain — smaller molecule, targeted tissue repair.

Read Guide →

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This content is for informational and educational purposes only. CJC-1295 DAC is sold for research purposes. Never Natty does not condone or encourage the use of any substance in violation of any laws. Consult a healthcare professional before using any compound discussed on this site.